摘要：OA-1 CXCR2 Antagonism Promotes Oligodendrocyte Precursor Cell Differentiation and Enhances Remyelination in A Mouse Model of Multiple Sclerosis WANG Lu,YANG Han-yu,ZANG Cai-xia,DONG Yi,SHANG Jun-mei,CHEN Jia-jing,WANG Yue,LIU Hui, ZHANG Zi-hong,XU Heng,BAO Xiu-qi,ZHANG Dan State Key Laboratory of Natural Products and Functions,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,100050,China 【ABSTRACT】 Multiple sclerosis(MS) is a chronic autoimmune demyelinating disease characterized by the autoimmune attack of oligodendrocytes,leading to demyelination and progressive functional deficits. CXC chemokine receptor 2 (CXCR2) is recently reported to orchestrate the migration,proliferation and differentiation of oligodendrocyte precursor cells (OPCs),which implies its possible involvement in the demyelinating process. Here,we used a CXCR2 antagonist,compound 2,as a tool to investigate the role of CXCR2 in demyelination and the underlying mechanism. The primary cultured oligodendrocytes and cuprizone (CPZ)- intoxicated mice were applied in the present study.